Dr. Richard Londraville
Title: Professor
Dept/Program: Biology
Office: ASEC C312
Phone: 330-972-7151
Fax: 330-972-8445
Email: londraville@uakron.edu
Website:
Biography
I'm a fish guy—I study how fish do what they do. I'm also a fat guy—I'm interested in what cells and organisms do with fat. Finally, I'm a temperature guy—I spend time thinking about how temperature affects cell function.For the past 15 years or so, we have focused on the hormone leptin. Leptin is famous for being the ‘fat control’ hormone in humans, and it has received LOTS of scientific attention (~50,000 studies). Our assertion is that we don’t know enough about how leptin evolved-and that by studying its evolutionary history, we will have a better understanding of how it works in humans. We have spent most of our time studying leptin in zebrafish (with Qin Liu), but also have studies in lizards (with Peter Niewiarowski), birds (with Joel Duff and Jeremy Prokop), and whales (with Hope Ball and Joel Duff). We use lots of molecular techniques, including CRISPr, qPCR, next-generation sequencing, bioinformatic analyses, and protein expression techniques.
Education
1994 Ph.D. University of Maine, Orono
Selected Publications
Londraville Richard L., Tuttle Matthew, Liu Qin, Andronowski Janna M. 2022. Endospanin is a candidate for regulating leptin sensitivity. Front. Physiol. 12:2307 https://www.frontiersin.org/article/10.3389/fphys.2021.786299
Buo C, Taylor E , Dayal P , Bartles J, Christman K & Londraville RL. 2020. Spatial mapping influences navigation in Entomacrodus striatus. Mar Fr Water Behav Physiol. https://doi.org/10.1080/10236244.2020.1785878
Cohn E, Cole P, Haymaker A, Garner AM, Londraville RL. 2020. Response to underwater laser pointer in the Orange-finned Anemonefish Amphiprion chrysopterus and three-spot damselfish Dascyllus trimaculatus. J Fish Biol. 96:274-277. https://doi.org/10.1111/jfb.14192
Tuttle M, Dalman MR, Liu Q, Londraville RL. 2019. (Danio rerio) PeerJ 7:e6848
R.L. Londraville, Prokop J. W., Duff R. J., Liu Q., Tuttle M. 2017. . Front. Endocrin. 8:58.
H. C. Ball, R. L. Londraville, J. W. Prokop, J. C. George, R. S. Suydam, C. Vinyard, J. G. M. Thewissen, R. J. Duff 2017. . J. Comp. Physiol. B. Jan;187(1):235-252. doi: 10.1007/s00360-016-1029-6. Epub 2016 Aug 29.doi:10.1007/s00360-016-
1, 1, 1, 1, 1, 2. 2016. Krüpple-like factors 7
1, , , , , , , . 2015. Seasonal and ontogenetic variation in subcutaneous adipose of the bowhead whale (Balaena mysticetus). 298(8) 1416-1423.
1, 2, 2, 2, 2, 2. 2014. 2014 Jun;52(3):T29-42. doi: 10.1530/JME-14-0050.
1, 2, 2, 2, 2, 3, 2, 2, 4, 5, 2. 2014. 2014 Mar 24;9(3):e92751. doi: 10.1371/journal.pone.0092751. eCollection 2014.
1, 2, 3, 4, 3, 4. 2014. . 2014 Jul 1;203:146-57. doi: 10.1016/j.ygcen.2014.02.002. Epub 2014 Feb 11.
Dalman MR, Liu Q, King MD, Bagatto B and Londraville RL (2013) . Front. Physiol. 4:160. doi: 10.3389/fphys.2013.00160
Ball, H.C., Holmes, R.K., Londraville, R.L. Thewissen, J.G.M., Duff, R.J. 2013. . PLOS One. 8(1) e542771-11.
Prokop, J.W., R.J. Duff, H.C. Ball, D.L. Copeland, R.L. Londraville. 2012. . Peptides 38:326-336
Chen, Y., Londraville, R.L., Brickner, S., El-Shaar, L., Fankhauser, K., Dearth, C., Fulton, L. Sochacka, A., Bhattarai, S., Marrs, J.A., Liu, Q., 2012. . Dev. Neurobiol. Aug 28 doi: 10.1002/dneu.22053
Q. Liu, M. Dalman, Y. Chen, M. Akhter, S. Brahmandam, Y. Patel, J. Lowe, M. Thakkar, A. Gregory, D. Phelps, C. Riley, and R.L. Londraville. 2012. Gen. Comp. Endocrinol. 178 (3) 562-572.
D. L. Copeland, R.J. Duff, Q. Liu, J. Prokop, and R.L. Londraville. 2011. Front. Aquat. Physiol. June 2011 Vol 2 Article 26
R.L. Londraville and Niewiarowski, P.H. 2010. Leptin signaling systems in reptiles and amphibians. In: Leptin in Non-Mammalian Vertebrates. Ed. by M. Paolucci. Published by Research Signpost, Kerala, India.
Q. Liu, Chen, Y. Copeland, D. Ball H., Duff, R.J., Rockich, B., Londraville, RL. 2009. . Gen. Comp. Endocrinol. Available online 11/24/09.
Heflin, B., Young, L., and R. Londraville. 2009. Short-term cycling of skin colouration in the blackspotted rockskipper Entom
DOI: 10.1111/j.1095-8649.2009.
Jury, D.R., Kaveti, S., Duan, Z-H, Willard, B., Kinter, M. and R. Londraville. 2008. Effects of calorie restriction on the zebrafish proteome. Comp. Biochem. Physiol. D. 3:275-282.
Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G. Fatkins. 2008. Cadherin-6 function in zebrafish retinal development. Develop. Neurobiol. Published online May 27 2008.
Liu, B., R.J. Duff, R. L. Londraville, J.A. Marrs and Q. Liu. 2007. Cloning and expression analysis of cadherin 7 I n the central nervous system of the embryonic zebrafish. Gene Express. Patterns 7(1-2) 15-22 .
Spanovich, S., Niewiarowski, P.H., and R. L. Londraville. 2006. Seasonal effects on circulating leptin in the lizard Sceloporus undulatus from two populations. Comp. Biochem. Physiol. B 143: 507-513.
Crockett, E.L. and R. L. Londraville. 2005. Temperature. In: The Physiology of Fishes 3rd Edition. CRC Press.
Liu Q, and R. L. Londraville. 2003. Using adult zebrafish visual system to study cadherin-2 expression during central nervous system regeneration. Methods Cell Sci. 00:1-8.
Tschantz, D.R., E.L. Crockett, P.H. Niewiarowski, and R.L. Londraville. 2002. Cold acclimation strategy is highly variable among the sunfishes (Centrarchidae) Physiol. Biochem. Zool. 75:544-556.
R. L. Londraville and C.S. Duvall. 2002. Murine leptin injections increase intracellular fat metabolism in green sunfish (Lepomis cyanellus) Gen. and Comp Endocrin. 129:56-62.
Liu Q., R.L. Londraville, E. Azodi, S.G. Babb, C. Chiappini, J.A. Marrs, and P. A. Raymond. 2002. Up-Regulation of Cadherin-2 and Cadherin-4 in Regenerating Visual Structures of Adult Zebrafish. Experimental Neurology 177:396-406
R.L. Londraville, T. D. Cramer, J.P.C. Franck, A. Tullis, and B.A. Block. 2000. Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans). Comp. Biochem. Physiol. B 127:223-233.
Johnson, R.M., T.M. Johnson, and R.L. Londraville. 2000. Evidence for leptin expression in fishes. J. Exp. Zool. 286(7):718-724
Niewiarowski, P.H., M.L. Balk, and R.L. Londraville. 2000. Murine leptin injection raises metabolic rate in an ectotherm. J. Exp. Biol. 203 (2):295-300